Computational methods for integrated analysis of omics and pathway data
نویسنده
چکیده
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1. GENERAL INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. A COMPUTATIONAL PLATFORM TO MAINTAIN AND MIGRATE MANUAL FUNCTIONAL ANNOTATIONS FOR BIOCYC DATABASES 9 Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Implementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Results and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Use Case: MaizeCyc and CornCyc GO Term Annotation Migration . . . . . . . 17 Use Case: Creating Strain-specific EcoCyc Databases . . . . . . . . . . . . . . . 19 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3. THE QUALITY OF METABOLIC PATHWAY RESOURCES DEPENDS ON INITIAL ENZYMATIC FUNCTIONAL ASSIGNMENTS AND LEVEL OF MANUAL CURATION: A CASE FOR MAIZE . . . . . . . . . . . . . . 33 Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
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تاریخ انتشار 2016